Week 24 MLS Picks

Written By The North End Pod

Coming off yet another profitable matchday, we were a Myrto Uzuni goal away from an absolute smash. We’ll take it and shift our focus to the midweek where we’ve got a full MLS slate on Wednesday night.

Before we get to the picks as normal, another reminder that we’ve got an addition to this weekly article in 2025. If you’ve been following along with the podcast during the offseason, you’ll know we’ve partnered with Underdog Fantasy. If you want to play along with us at Underdog, you can sign up today using this link and when you use promo code "NORTHEND" at sign up you'll get up to $1000 in bonus cash plus a free pick!

The official league injury report for Wednesday’s games came out Teusday afternoon, let’s dive into the Week 24 picks.

Underdog Fantasy Entry of the week

Each match week, we’ll have an Underdog Fantasy entry for you to tail if your heart desires. Let’s get to the board and build a winner!

We’ll start our midweek entry by backing Inter Miami against FC Cincinnati on the road and taking Roman Celentano’s goals allowed. With Messi and friends not on the injury report, it’s really tough to pass up a chance to take them at this number. Inter Miami hasn’t been up to expectation in the league to this point of the season, but they’re still averaging two goals per game. They’ve scored two or more goals in 13 of their 19 league games this season and are -135 at the books to do so on Wednesday.

Then we’ll head to New Jersey where the Red Bulls are hosting the Revolution. Leo Campana came off the bench in Austin over the weekend, signaling a likely start in this one. The former Inter Miami striker is averaging 3.45 shot attempts per 90 minutes this season and has gone over this number in six of the nine games he’s played 62 or more minutes this season. At a 1.11x multiplier and Carles Gil feeding him the rock, we’re backing Campana.

To close out the entry, we’re going back to a very familiar face. Nashville SC are one of the hottest teams in the league right now, especially at home. They play host to Columbus Crew on Wednesday, with both teams tied on 41 points, just two points back of first place Philadelphia Union. Hany Mukhtar has averaged 1.95 shots on target per 90 minutes this season, but has been even stronger at home in 2025, going over this number in eight of his 11 appearances at Geodis Park.

Using the standard payout selection on Underdog, this 3-pick entry will payout a prize of 6.66x your entry fee if successful.

We’ve added some additional plays that can be substituted in place of the props given above if you miss lock for one of those games or one of those options doesn’t start. The additional plays this week are listed in order of preference and we’re fine using these props in any entry.

  • Evander O 1.5 shots on target (1.06x)

  • Christian Benteke O 3.5 shots attempted (1.17x)

  • Denis Bouanga O 1.5 shots on target

  • Patrick Schulte O 1.5 goals allowed

  • Myrto Uzuni O 2.5 shots attempted (1.04x)

Results

Underdog Fantasy (Last Week): -1 U

Underdog Fantasy (Season): +16.98 U

Week 24 Picks

INter Miami

+135

Not the easiest matchup in the world for Messi and Co. on Wednesday night headed into TQL Stadium to take on the Knifey Lions, with both teams squarely tucked into the top five in the Eastern Conference. Inter Miami has found their form in the league of late, winning five straight MLS matches coming into the midweek. Being able to back the GOAT at this number always feels good, even against FC Cincinnati, who will be without the likes of Kevin Denkey and Obinna Nwobodo.

Houston Dynamo

ML +115

It never feels good to back the success of our most hated rival, but the Dynamo are in a good spot tonight against the Whitecaps of all teams. Vancouver has taken some big steps backward since their 5-0 drubbing in the CCC Final. They’ve lost four of their last five league matches and will be without a number of key players, including Pedro Vite, who was just sold to Pumas this week. Tristan Blackmon and Andres Cubas are also listed as questionable, while Houston will have Jack McGlynn fully reintegrated from his Gold Cup stint with the USMNT.

Portland Timbers

ML +130

The Timbers have been a results roller coaster over the last month, with a home victory over New England sandwiched by a 3-0 road loss to lowly Toronto FC and a 2-1 defeat to St. Louis City SC last Sunday night. But they’re back in the friendly confines of Providence Park on Wednesday to host Real Salt Lake and we can’t pass up Portland at this number. The Timbers are the second best home team in the Western Conference to this point of the season, with 22 points from their 11 matches. Portland to win at plus money.

Austin FC

Double Chance -120

Slight homer alert? The vibes are uncertain at best in ATX right now, who travel out to Carson to take on last place LA Galaxy in the midweek. Questions remain surrounding how Austin FC will fill the void left in the wake of the Brandon Vazquez injury, but they did generate five big chances against New England over the weekend despite not finding the back of the net. Getting our favorite team on the double chance within our juice range against the team with the most goals conceded in 2025 is something we just aren’t going to pass up.

Goal Scorers 

Every week we’ll pick a few of our favorite goal scoring options in the betting market. Here are the Week 24 shouts.

  • Evander +140

  • Luca Orellano +320

  • Leo Campana +270

  • Christian Benteke +175

  • Miguel Almiron +205

  • Philip Zinckernagel +250

  • Hany Mukhtar +165

  • Denis Bouanga +155

  • Lawrence Ennali +340

  • Griffin Dorsey +950

  • Djordje Milhailovic +320

  • Myrto Uzuni +250

Results

Last Week: +3.98 U

Season: +34.72 U

The North End Pod
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