Week 25 MLS Picks

Written By The North End Pod

The goals props continue to carry us in 2025 as we smashed the books for double digit units in the midweek games. We’re now north of 60 units overall on the season, let’s keep climbing.

Before we get to the picks as normal, another reminder that we’ve got an addition to this weekly article in 2025. If you’ve been following along with the podcast during the offseason, you’ll know we’ve partnered with Underdog Fantasy. If you want to play along with us at Underdog, you can sign up today using this link and when you use promo code "NORTHEND" at sign up you'll get up to $1000 in bonus cash plus a free pick!

The official league injury report for Saturday’s games came out Friday afternoon, let’s dive into the Week 25 picks.

Underdog Fantasy Entry of the week

Each match week, we’ll have an Underdog Fantasy entry for you to tail if your heart desires. Let’s get to the board and build a winner!

Beginning this weekend’s entry in New England where the Revolution play host to Orlando City SC. Marco Pasalic has been on fire of late and Orlando has been one of the best road teams this season, recording 17 points from their 11 matches. Pasalic is averaging 3.47 shot attempts per 90 in 2025 and has gone over this number in 13 of the 18 matches he’s played 72 minutes or more. These teams already met in Orlando earlier in the year, where Pasalic recorded three shot attempts. The Revs are also giving up the second most shot attempts per 90 to opponents in 2025, so we’re rolling this with confidence at a 1.02x multiplier.

Then we’ll go back to old reliable. Even at an 0.81x multiplier, Lionel Messi’s shots on target prop is extremely strong. He’s averaging 2.32 shots on target per 90 minutes this season and in league play he’s recorded two or more shots on target in 16 of his 17 appearances. Inter Miami is coming off a midweek beatdown at the hands of FC Cincinnati, snapping their five match win streak and now looking to get back to their winning ways against New York Red Bulls, who are in the top half of shots on target allowed to opponents.

To close out this weekend’s entry, we’ll head to El Trafico and target DP winger Gabriel Pec. The Galaxy are bad, but Pec’s shot attempts line is very strong at a 1.01x multiplier. Pec is averaging 3.94 shot attempts per 90 this season and has been over this number in 14 of his 20 appearances this year. He’s also been over this number in three of his four career games against LAFC.

Using the standard payout selection on Underdog, this 3-pick entry will payout a prize of 5x your entry fee if successful.

We’ve added some additional plays that can be substituted in place of the props given above if you miss lock for one of those games or one of those options doesn’t start. The additional plays this week are listed in order of preference and we’re fine using these props in any entry.

  • Evander O 3.5 shots attempted (1.22x)

  • Chicho O 3.5 shots attempted (1.24x)

  • Brad Guzan O 1.5 goals allowed (1.12x)

  • Jonathan Sirois O 1.5 goal allowed

Results

Underdog Fantasy (Last Week): -1 U

Underdog Fantasy (Season): +15.98 U

Week 25 Picks

INter Miami

+180

While Inter Miami looked sluggish on Wednesday in Cincinnati, none of the Barcelona boys are on the injury report headed into Saturday’s road tilt against New York Red Bulls. Getting Messi and friends at almost two to one is just too juicy for us to pass up, even if they are struggling a bit in the eye test department. The Red Bulls will also be without Lewis Morgan and Cameron Harper in their attack. Inter Miami to win.

Chicago fire

ML +130

The Fire have been inconsistent in 2025, but they’re one of the best road teams in the league and are the highest scoring team away from home by a wide margin, with 31 goals scored in 12 road games (the next closest team is San Diego FC with 24 goals in 11 games). Now they’re north of the border to take on last place CF Montreal, who have just one home win in ten tries with a negative 14 goal differential. We’re backing Chicago to bring home all three points on Saturday.

FC Cincinnati

ML +235

The Knifey Lions are riding high after dismantling Inter Miami in the midweek. Now they’ll face a Real Salt Lake side that is very much in form, winning three straight and four of their last five. Over the course of the season, RSL has been a below average team at home, even with the elevation advantage they have in Utah. Cincy will be without Kevin Denkey up top once again, but they have more than enough depth in their attack to get the job done here and the odds are too good to pass up.

Vancouver Whitecaps

Double Chance -125

The Whitecaps have taken a step back after getting throttled in the CCC Final about seven weeks ago. Even with that break in form, they’re just a point back of San Diego FC (their opponent this weekend) for the Western Conference lead with a game in hand. They’ll also see the return of Andres Cubas on Saturday, a very important addition after the team sold Pedro Vite to Pumas this week. While they are rightfully underdogs in this spot, the double chance is a little too close to even money for us to ignore. Both of San Diego’s starting CBs are listed questionable on the injury report headed into this one, so we’ll take Vancouver to win or draw on Saturday night.

Goal Scorers 

Every week we’ll pick a few of our favorite goal scoring options in the betting market. Here are the Week 25 shouts.

  • Miguel Almiron +225

  • Leo Campana +205

  • Marco Pasalic +235

  • Phillip Zinckernagel +225

  • Ezequiel Ponce +200

  • Chicho +230

  • Cedric Teuchert +310

  • Evander +195

  • Luca Orellano +550

  • Gabriel Pec +330

  • Joseph Paintsil +350

Results

Last Week: +10.33 U

Season: +45.05 U

The North End Pod
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Week 24 MLS Picks