Week 25 MLS Picks
Last weekend’s results were up and down throughout the slate and ended up settling as a slight loss overall. We’ve got a full midweek slate ahead so we dust ourselves off and get back to it.
The official league injury report for Wednesday’s games came out Tuesday afternoon, let’s dive into the Week 25 picks.
Pick’Em Entry of the week
Unfortunately, Underdog Fantasy has decided to exit the MLS prop pick’em market at this time. So we’re going to pick things back up on PrizePicks for the time being. If you want to play along with us, you can sign up for PrizePicks through this link.
Though we came up just short on our three-pick entry over the weekend, we’re going back to another in the midweek.
This trio of fantasy score props are set too low for the roles that each of these guys play for their respective clubs. They’re all on set pieces along with being goal dangerous. Additionally, all three of them play at home on Wednesday, which typically sets a higher minutes floor on a double game week.
Using the standard payout selection on PrizePicks, along with the 30% profit boost token dropped into accounts on Wednesday, this three-pick entry will payout a prize of 7.5x your entry fee if successful.
Results
Last Week: -1.0 U
Season: +2.13 U
Week 25 Picks
Nashville SC
ML +125
Double game weeks always bring a little extra uncertainty when it comes to lineup rotation. But Nashville SC are far and away the top team in MLS at the moment, sitting a full ten points clear of not just the rest of the Eastern Conference, but the entire league. They’ve got a +30 goal differential and have only conceded 0.74 goals per game in 2026. They’re on the road north of the border on Wednesday to take on Toronto FC. The home side will be without their DP midfielder Djordje Mihailovic in this one and while Nashville may employ some rotation amongst their regular starters with a matchup against Inter Miami looming this weekend, they’ve pulled off multiple wins (to our detriment) with heavily rotated sides this season. We’ll take the top team in the league to win on the road at plus money against 11th place Toronto.
INter Miami
ML +185
Expect some fireworks in this match. Considering the recent history between these two clubs, especially since Lionel Messi arrived in MLS, we took a long hard look at the total in this one before deciding to just back Inter Miami to earn all three points here. As much as they’ve “struggled” in 2026, Miami are still tied for second in the shield standings and have actually been the league’s best road side to this point of the year, earning a massive 26 points from their 12 road fixtures. Chicago is right on their heels in the table, sitting five points back with a game in hand, but we’re going to back the (at least slightly) more talented side in this spot at nearly two-to-one.
PHI/CIN O 2.5 + MIN/DAL U 3.5
Parlay +117
We’ve been having decent success with the parlays of late so we’re going back to a pair of them in Week 25. We begin with a pair of totals and the first is an old reliable for us. FC Cincinnati is on the road to take on the surging Philadelphia Union, who have not just climbed out of their wooden spoon position they sat in all summer during the World Cup, they’re currently occupying a wild card spot in the Eastern Conference after earning 20 points from their eight league matches since returning to play. If you’re a regular here you know that Cincy matches go over a 2.5 total quite frequently. In fact, 15 of their 22 (68.1%) league games this season have gone over this number and those 22 matches have seen an average of 4.55 goals scored.
Then we pair that with the under in Minnesota, where the Loons are hosting FC Dallas. Golden boot leader Petar Musa is listed as questionable on the Frisco injury report and if he’s limited on Wednesday it greatly diminishes the offensive threat posed by the visitors. The Loons have also been abysmal at home this season, with their 11 home matches averaging just two goals per game. Dating back to November 2020, these two teams have squared off 14 times and gone under this number in 13 of those games. These two picks give us a nice plus-money parlay of totals for our midweek action.
Austin FC
ML +145
Obligatory bias alert: Austin FC is not a good MLS team. Their roster is decimated after a summer transfer window that saw names like Owen Wolff, Dani Pereira and Jayden Nelson depart the club. But in the midweek they’ll welcome the Colorado Rapids to town who are one of the worst road teams in MLS this season, with just seven points from their 12 road matches. They haven’t just lost all three of their away matches since the World Cup break, they haven’t scored a goal on the road since May 16th. With ATX in as close to a must-win spot as they can be to stay attached to the wild card race, we’ll take them to win at home.
LAFC to Win + Vancouver Whitecaps To Win
Parlay -102
We’ll close out our midweek slate with a favorites money line parlay at near even money. First we’re going back to LAFC, who are fresh off blowing a lead over RSL twice on Saturday night. The current run of six winless league games is unprecedented for a team like LAFC, fortunately for them they have a “get right” spot on Wednesday in the form of the New York Red Bulls. After a relatively fast start to the season the Red Bulls are in horrendous form at the moment, earning just five points from their last eight league games. With the Black and Gold taking on spoon favorites SKC this Saturday, we expect them to pour everything into ending their winless streak on Wednesday.
Then we go back to the Whitecaps after Saturday’s surprising home loss against St. Louis City SC. Vancouver is taking on the somewhat new-look LA Galaxy at BC Place in the midweek and are the biggest favorites on the slate at the books. The Caps are the Western Conference’s best home side so far this season, even accounting for the 3-1 weekend loss, they’ve only conceded nine total goals in their 12 games at BC Place. We expect them to get back on track with a win in this spot.
Goal Scorers
Every week we’ll pick a few of our favorite goal scoring options in the betting market. Here are the Week 25 shouts.
Pep Biel +200
Santiago Rodriguez +330
Breel Embolo +140
Antoine Griezmann +170
Evander +205
Peyton Miller +400
Philip Zinckernagel +195
German Berterame +225
Facundo Torres +340
Joseph Rosales +950
Mateusz Bogusz +225
Morgan Guilavogui +380
Kristoffer Velde +225
Hirving Lozano +370
To Score Two Or More Goals
Facundo Torres +2800 (0.5 U)
To Score Or Assist
Allan Saint-Maximin +175
Brais Mendez +150
Elias Saad +215
Jack Harrison +220
Diego Luna +205
Eduard Lowen +190
To Score Or Assist Two Or More Goals
Brais Mendez +950
Elias Saad +1600
Diego Luna +1500
Results
Last Week: -3.15 U
2026 Season: +5.85 U
